![]() ![]() Their chemistry has been therefore examined thoroughly.Īn important factor for cosmetic emulsions is their antioxidant stability. ![]() Emulsion products are used worldwide in the cosmetic and pharmaceutical industry for numerous applications besides skin moisturization, including cosmetic products and the dermal or transdermal drug delivery of various active pharmaceutical ingredients (APIs). Basic everyday skin care is mostly done through emulsions whose ultimate purpose is the increase of the water content located in the outermost layer of the epidermis, stratum corneum. Its proper hydration is of great importance for a non-flaky, healthy skin appearance. ![]() Skin is the largest organ of the human body and is continuously exposed to oxidative stress caused by the ultraviolet (UV) radiation or due to endogenous factors, namely enzymes. Enhanced antioxidant and antimicrobial properties due to the phenolic compounds of PJ were also observed. ![]() All produced emulsions exhibited good pH and viscosity stability for up to 90 days, while the sun protection factor (SPF) was enhanced due to the presence of the PJ. The resulted PJ-loaded nanoparticles were further utilized for the preparation of innovative O/W cosmetic emulsions. High-performance liquid chromatography coupled with photodiode array and electrospray ionization mass spectrometry detection (LC-PDA-ESI/MS) revealed that PJ active compounds were successfully and in sufficient amounts encapsulated in the nanoparticles interior, whereas XRD indicated a crystalline structure alteration after nanoencapsulation. Dynamic Light Scattering (DLS) revealed nanoparticles sizes varying between 426 nm and 4.5 μm, indicating a size-dependence on the polymer concentration used during encapsulation. Filtered fresh pomegranate juice (PJ) was loaded in nanoparticles of neat CS and its derivative via ionic gelation method. Its crystallinity was studied by X-ray Diffraction (XRD), while in vitro cytotoxicity and cell viability assays established its biocompatibility. The successful synthesis of CS-SDAEM was confirmed by Fourier-transform Infrared (FTIR) and Nuclear Magnetic Resonance ( 1H-NMR) spectroscopies. In the present study, a chitosan (CS) derivative with the 2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SDAEM) zwitterionic monomer was prepared through chemical modification. ![]()
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